Pediatric Pulmonology 41:1218–1225 (2006) Multiple Breath Washout With a Sidestream Ultrasonic Flow Sensor and Mass Spectrometry: A Comparative Study
نویسندگان
چکیده
Over recent years, there has been renewed interest in the multiple breath wash-out (MBW) technique for assessing ventilation inhomogeneity (VI) as ameasure of early lung disease in children. While currently considered the gold standard, use of mass spectrometry (MS) to measure MBW is not commercially available, thereby limiting widespread application of this technique.Amainstreamultrasonic flowsensorwasmarketed forMBWa fewyears ago, but its use was limited to infants. We have recently undertaken intensive modifications of both hardware and software for the ultrasonic system to extend its use for older children. The aim of the current in vivo studywas to comparesimultaneousmeasurements of end-tidal tracergas concentrationsand lung clearance index (LCI) from this modified ultrasonic device with those from a mass spectrometer. Paired measurements of three MBW, using 4% sulfur hexafluoride (SF6) as the tracer gas and the two systems in series, were obtained in nine healthy adult volunteers. End-tidal tracer gas concentrations (n1⁄4675 paired values) demonstrated close agreement (95% CI of difference 0.23; 0.17%, r1⁄4 1). FRCwasslightly higher from theMS (95%CI0.08;0.17L), but therewasno difference in LCI (95%CI 0.10; 0.3).We conclude, that this ultrasonic prototypesystemmeasures end-tidal tracer gas concentration accurately and may therefore be a valid tool for MBW beyond early childhood. This prototype system could be the basis for a commercial device allowing more widespread application of MBW in the near future. Pediatr Pulmonol. 2006; 41:1218–1225.
منابع مشابه
Equipment for multiple breath washout.
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